ESAT-6 Subunit Vaccination against Mycobacterium tuberculosis
نویسندگان
چکیده
منابع مشابه
ESAT-6 subunit vaccination against Mycobacterium tuberculosis.
The ESAT-6 antigen from Mycobacterium tuberculosis is a dominant target for cell-mediated immunity in the early phase of tuberculosis (TB) in TB patients as well as in various animal models. The purpose of our study was to evaluate the potential of ESAT-6 in an experimental TB vaccine. We started out using dimethyl dioctadecylammonium bromide (DDA), an adjuvant which has been demonstrated to be...
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Tuberculosis is still one of the important infectious diseases and a major cause for public health problems, particularly in lowand middle-income countries. Prevention of this disease is a priority of WHO. Many antigens have been candidate for vaccination. Evaluating the safety and efficacy of these antigens is the concern of many researchers. This review is about ESAT-6 as an effective Mycobac...
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Mycobacterium tuberculosis 6-kDa early secretory antigenic target (ESAT-6) is a dominant target antigen for cell-mediated immunity in the early phase of tuberculosis. The fms-like tyrosine kinase 3 ligand (FL) that induces potent immune response has been used as an adjuvant in vaccine development. In this study, a new recombinant plasmid (pIRES-epitope-peptides-FL) encoding three T cell epitope...
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ژورنال
عنوان ژورنال: Infection and Immunity
سال: 2000
ISSN: 0019-9567,1098-5522
DOI: 10.1128/iai.68.2.791-795.2000